含细菌的肠绒毛

含细菌的肠绒毛

微生物组基础知识

gut microbiome icon

肠道微生物组

胃肠道是身体与环境的最大接触面。1肠道的作用远远不止消化。

虽然胃肠道（肠道）是食物消化和营养吸收的中心，但它对宠物的整体健康也起着关键作用。

肠道微生物组的已知功能包括：2、3

  • 收集食物以作为能量
  • 通过发酵和代谢活动为宿主提供营养
  • 分解膳食纤维
  • 形成免疫系统并维持稳态
  • 处理多糖和维生素
  • 产生激素
  • 抵御肠道病原体

肠道是数百种不同的细菌和其他微生物（如原生动物、古生菌、病毒和真菌）的家园。

肠道中寄生着数以亿计的微生物 - 肠道中的微生物细胞数量至少与全身细胞数量相同。4当前文献估计有 1010-1014 个微生物细胞。2这些常居微生物（或共生菌）在能量调节、矿物质吸收、维生素合成、肠道屏障功能和免疫系统功能中发挥作用。它们还能提供抵抗病原体的屏障，并帮助滋养肠道。

代表性相对丰度普通细菌

代表性相对丰度普通细菌

肠道微生物组构成了肠道和大脑之间双向相互作用的关键部分，称为肠脑轴，5越来越多的证据表明，微生物组会影响其他器官的健康，如皮肤、6心脏和肾脏。

 

肠道微生物组相互作用

探索Microbiome Forum的其他部分

以微生物组为中心

以微生物组为中心的宠物健康状况干预

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雀巢领导力缩略图

Nestlé 和 Purina 在微生物组领域的领先地位

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  1. Richards, P., Thornberry, N. A., & Pinto, S. (2021). The gut-brain axis: Identification of new therapeutic approaches for Type 2 diabetes, obesity, and related disorders. Molecular Metabolism, 46, 101175. doi:10.1016/j.molmet.2021.101175
  2. Belas, A., Marques, C., & Pomba, C. (2020). The gut microbiome and antimicrobial resistance in companion animals. In Duarte, A. & Lopes da Costa, L. (Eds.), Advances in Animal Health, Medicine and Production (1st ed.), pp. 233–245. Springer International Publishing
  3. Blake, A. B. & Suchodolski, J. S. (2016). Importance of gut microbiota for the health and disease of dogs and cats. Animal Frontiers, 6(3), 37—42. doi:10.2527/af.2016-0032
  4. Sender, R., Fuchs, S., & Milo, R. (2016). Revised estimates for the number of human and bacteria cells in the body. PLoS Biology, 14(8):e1002533. doi:10.1371/journal.pbio.1002533
  5. Oriach, C. S., Robertson, R. C., Stanton, C., Cryan, J. F., & Dinan, T. G. (2016). Food for thought: The role of nutrition in the microbiota-gut-brain axis. Clinical Nutrition Experimental, 6, 25–38.
  6. van Splunter, M., Lui, L, Joost van Neerven, R. J., WIchers, H. J., Hettinga, K. A., & de Jong, N. W. (2020). Mechanisms underlying the skin-gut cross talk in the development of IgE-mediated food allergy. Nutrients, 12, 3830. doi:10.3390/nu12123830
  7. Summers, S. C., Quimby, J. M., Isaiah, A., Suchodolski, J. S., Lunghoger, P. J., & Gustafson, D. L. (2019). The fecal microbiome and serum concentrations of indoxyl sulfate and p-cresol sulfate in cats with chronic kidney disease. Journal of Veterinary Internal Medicine, 33(2), 662–669. doi:10.1111/jvim.15389
  8. Suchodolski, J. S., Camacho, J., & Steiner, J. M. (2008). Analysis of bacterial diversity in the canine duodenum, jejunum, ileum, and colon by comparative 16S rRNA gene analysis. FEMS Microbiology Ecology, 66, 567–578.
  9. Suchodolski, J. S. (2011). Microbes and gastrointestinal health of dogs and cats. Journal of Animal Science, 89, 1520—1530. doi:10.2527/ jas.2010.3377
  10. Suchodolski, J.S. (2011). Intestinal microbiota of dogs and cats: a bigger world than we thought. Veterinary Clinics of North America Small Animal Practice, 41, 261—272. doi:10.1016/j. cvsm.2010.12.006
  11. Suchodolski, J.S. (2012). “Microbiota in health and disease.” Nestlé Purina Companion Animal Nutrition Summit, Lisbon, Portugal, pp. 33–37.
  12. Honneffer, J. B., Steiner, J. M., Lidbury, J. A., & Suchodolski, J. S. (2017). Variation of the microbiota and metabolome along the canine gastrointestinal tract. Metabolomics, 12, 26. doi:10.1007/s11306-017-1165-3