
含细菌的肠绒毛

肠脑轴
“肠脑轴”一词是指胃肠道和大脑之间持续的双向沟通交流。
肠道影响大脑,进而影响行为的观点已被广泛理解和接受。此概念早已融入日常用语,我们会使用“直觉(gut feeling;gut = 肠)”、“勇敢(gutsy;gut = 肠)”和“忐忑不安(butterflies in the stomach;stomach = 胃)”等词语。尽管如此,科学家们直到最近才开始解开肠脑轴背后的机制。 这种沟通联系是一个新兴研究领域 – 神经胃肠病学的核心。

越来 越多的证据表明,肠道微生物有助于形成正常的神经发育、大脑生物化学和行为。1特别是肠道微生物群正在成为肠道和大脑之间沟通的关键节点。这导致了一个新术语的诞生:微生物群肠脑轴。


肠绒毛与细菌
研究表明,肠道细菌与肥胖、阿尔茨海默病和宠物焦虑等疾病有许多联系。2-4后者很重要,因为多达 70% 的犬行为障碍可归因于某种形式的焦虑。5
兽医全科医生在鉴别和治疗患病宠物行为问题(如焦虑)方面的作用至关重要。6

宠物主人可能不会识别出所有的恐惧和焦虑体征,或者可能只在问题升级到危象状态时才前往就医。7
焦虑的后果



Purina 的研究

在一项盲法交叉研究中,Purina 的科学家发现,与喂食安慰剂的犬相比,喂食特定菌群 - 长双歧杆菌 (BL999) 的犬的焦虑行为显著减少。喂食 BL999 的大多数犬的心率和唾液皮质醇水平也较低。从行为和生理角度来看,B. longum BL999 对焦虑患犬均有减轻焦虑的作用。

探索Microbiome Forum的其他部分
了解更多信息
- Shen, H. H. (2015).Microbes on the Mind. Proceedings of the National Academy of Sciences, 112(30), 9143–9145. doi:10.1073/pnas.1509590112
- Dinan, T. G., & Cryan, J. F. (2017).Gut–brain axis in 2016: Gut-brain axis in 2016: Brain-gut-microbiota axis - mood, metabolism and behaviour. Nature Reviews Gastroenterology & Hepatology, 14(2), 69–70. doi: 10.1038/nrgastro.2016.200
- Köhler, C. A., Maes, M., Slyepchenko, A., Berk, M., Solmi, M., Lanctot, K. L., & Carvalho, A. F. (2016).The gut-brain axis, including the microbiome, leaky gut and bacterial translocation: Mechanisms and pathophysiological role in Alzheimer’s disease. Current Pharmaceutical Design, 22(40), 1–15. doi: 10.2174/1381612822666160907093807
- McGowan, R. T. S., Barnett, H. R., Czarnecki-Maulden, G. L., Si, X., Perez-Camargo, G., & Martin, F. (2018, July).Tapping into those ‘gut feelings’: Impact of BL999 (Bifidobacterium longum) on anxiety in dogs. Veterinary Behavior Symposium Proceedings, Denver, CO, pp. 8–9.
- Beata, C., Beaumont-Graff, E., Diaz, C. Marion, M., Massal, N., Marlois, N., Muller, G., & Lefranc, C. (2007). Effects of alpha-casozepine (Zylkene) versus selegiline hydrochloride (Selgian, Anipryl) on anxiety disorders in dogs. Journal of Veterinary Behavior, 2, 175–183.
- Stelow, E. (2018).Diagnosing behavior problems: A guide for practitioners. Veterinary Clinics of North America, 48(3), 339–350. doi:10.1016/ j.cvsm.2017.12.003
- Ballantyne, K. C. (2018). Separation, confinement, or noises: what is scaring that dog? Veterinary Clinics of North America: Small Animal Practice, 48(3), 367–386. doi:10.1016/j.cvsm.20112.005
- Salman, M. D., Hutchison, J., Ruch-Gallie, R., Kogan, L., New, J. C., Kass, P. H., & Scarlett, J. M. (2000).Behavioral reasons for relinquishment of shelter dogs and cats to 12 shelters.Journal of Applied Animal Welfare Science, 3(2), 93–106.
- Tanaka, A., Wagner, D. C., Kass, P. H., & Hurley, K. F..(2012).Associations among weight loss, stress, and upper respiratory tract infection in shelter cats.Journal of the American Veterinary Medical Association, 240(5), 570–576. doi: 10.2460/javma.240.5.570
- Landsberg, G., Hunthausen, W., & Ackerman, L. (2013).Behavior Problems of the Dog & Cat.Great Britain: Saunders Elsevier. pp. 181–182.
- Mills, D., Karagiannis, C., & Zulch, H. (2014). Stress – Its effects on health and behavior: A guide for practitioners.Veterinary Clinics of North America: Small Animal Practice, 44, 525–541.
- Mariti, C., Gazzano, A., Moore, J. L., Baragli, P., Chelli, L., & Sighieri, C. (2012).Perception of dogs’ stress by their owners.Journal of Veterinary Behavior, 7(4), 213–219.
- Seibert, L. M., & Landsberg, G. M. (2008).Diagnosis and management of patients presenting with behavior problems.Veterinary Clinics of North America: Small Animal Practice, 38, 937–950.
- Patronek, G. J., & Dodman, N. H. (1999).Attitudes, procedures, and delivery of behavior services by veterinarians in small animal practice. Journal of the American Veterinary Medical Association, 215(11), 1606–1611.