Epithelial barrier dysfunction, oxidant injury, and inflammation are common to both atopic dermatitis and chronic inflammatory enteropathy in dogs. These shared features are attractive targets for nutritional approaches to patient management.

Both gut and skin host highly interactive ecosystems that contribute to immune responses. Learn how dysbiosis of the skin microbiome correlates with atopic dermatitis and food allergies in people.

An overview of immune complex-mediated glomerular diseases of dogs and cats, including glomerular anatomy, classification, causative agents, pathogenesis, diagnostics, and clinical implications.

Expand your knowledge on how nutrition can be leveraged to modify inflammation and immunity.

Learn how the relationship between the gastrointestinal tract and the kidneys, known as the gut-kidney axis, is relevant to a discussion of constipation and chronic kidney disease in cats.

Is feline idiopathic cystitis merely inflammation of the bladder urothelium? What is the etiology of the inflammation? Learn the answers to these questions and others, including how to help affected cats.

Progression of chronic kidney disease in cats is multifactorial, poorly understood, and highly variable. Learn more about the eight factors that have been implicated in renal inflammation, fibrosis, and disease progression.

Explore the interplay between diet and the gut-associated immune system. From providing essential nutrients to modulating immune function, dietary interventions offer opportunities to optimize immune health and reduce immune-related disorders.

Arginine deficiency leads to severe metabolic abnormalities and immune dysfunction in human, feline, and canine patients. Learn about arginine deficiency syndrome, its consequences, and arginine replacement therapy in human medicine.

The gastrointestinal tract does more than digest food and absorb nutrients. It is the body’s largest immune organ and harbors an extensive microbial ecosystem. Here is a brief refresher on the intestinal immune system.

Normal immune and inflammatory responses are influenced by many factors, including aging and nutrition. Learn how specific nutrients can modify inflammatory and cell-mediated immune responses.

An expert panel discusses how new research and evidence-based guidelines are changing approaches to management of diarrhea in dogs and cats.