Association Between Intestinal Dysbiosis, NetF-Toxin-Encoding C. perfringens and Increased Intestinal Permeability in Dogs With Acute Hemorrhagic Diarrhea Syndrome

Speaker:

Andrea Reisinger, DVM

Event date: 9–10 November 2022 Virtual Event

Histopathological examination reveals the presence of necrotizing enteritis in dogs with acute hemorrhagic diarrhea syndrome (AHDS). Therefore, the presence of intestinal barrier dysfunction is suspected and may be associated with clinical severity.  

This study demonstrates that a subset of dogs with AHDS have increased intestinal permeability as assessed by serum iohexol evaluation. The increased intestinal permeability correlates with clinical severity. Microbiome changes are minor and transient. 

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