Chronic enteropathy in dogs is a common clinical problem with a poorly understood pathogenesis. Learn how transcriptomic studies are providing new insights into the mechanisms that contribute to clinical signs of chronic enteropathy.

Epithelial barrier dysfunction, oxidant injury, and inflammation are common to both atopic dermatitis and chronic inflammatory enteropathy in dogs. These shared features are attractive targets for nutritional approaches to patient management.

Both gut and skin host highly interactive ecosystems that contribute to immune responses. Learn how dysbiosis of the skin microbiome correlates with atopic dermatitis and food allergies in people.

Discover what is currently known about the role of acute intestinal injury in the development of chronic enteropathies and food allergies in dogs.

Learn how immune system dysregulation and reduced tolerance to otherwise innocuous food components result in development of food allergies in dogs.

An overview of immune complex-mediated glomerular diseases of dogs and cats, including glomerular anatomy, classification, causative agents, pathogenesis, diagnostics, and clinical implications.

Progression of chronic kidney disease in cats is multifactorial, poorly understood, and highly variable. Learn more about the eight factors that have been implicated in renal inflammation, fibrosis, and disease progression.

Explore the interplay between diet and the gut-associated immune system. From providing essential nutrients to modulating immune function, dietary interventions offer opportunities to optimize immune health and reduce immune-related disorders.

Arginine deficiency leads to severe metabolic abnormalities and immune dysfunction in human, feline, and canine patients. Learn about arginine deficiency syndrome, its consequences, and arginine replacement therapy in human medicine.

The gastrointestinal tract does more than digest food and absorb nutrients. It is the body’s largest immune organ and harbors an extensive microbial ecosystem. Here is a brief refresher on the intestinal immune system.

Normal immune and inflammatory responses are influenced by many factors, including aging and nutrition. Learn how specific nutrients can modify inflammatory and cell-mediated immune responses.

Learn how the relationship between the gastrointestinal tract and the kidneys, known as the gut-kidney axis, is relevant to a discussion of constipation and chronic kidney disease in cats.