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THERAPEUTIC NUTRITION

Useful information about the needs of cats and dogs with nutritionally sensitive health conditions.

Cardiovascular Disorders

Dietary Management of Myxomatous Mitral Valve Disease (MMVD)

Myxomatous mitral valve disease (MMVD) is the most common heart disease in dogs. Current nutritional guidelines focus on recommendations for dogs after they show evidence of cardiac changes. New research demonstrates that a blend of nutrients, the cardiac protection blend (CPB), may help improve heart function in the early stages of disease, before dogs show signs of heart failure.

teal canine heart icon

About 1 in 10 dogs has heart disease, and the characteristic left apical heart murmur in dogs with MMVD is typically recognized during a routine veterinary exam.1

Key Messages

  • Myxomatous mitral valve disease (MMVD) is the most common cause of acquired canine heart disease.1-3 
    • In North America, MMVD accounts for approximately 75% of canine heart disease.1
    • Most affected dogs are older, small breed dogs weighing less than 20 kg, although MMVD can also occur in larger dogs.1,4
       
  • Dogs with MMVD appear healthy until they reach later stages of disease. But, internally, the heart is changing even in this preclinical time.1
    • MMVD is a slowly progressive disease, but the rate of progression is hard to predict.1
    • Approximately 30% of dogs with MMVD progress to advanced disease.2,5 

  • Current nutritional recommendations focus mainly on managing signs after congestive heart failure starts. A study was done to identify metabolomic differences between dogs with MMVD and healthy controls. Based on this research, a cardiac protection blend (CPB) of nutrients was developed. A internal study indicated that the CPB may help improve heart function in dogs with early stage MMVD.1,6-8  

  • A 6-month dietary internal study using a diet with the CPB in a complete and balanced diet showed nutrition may play a role in the management of the early stages of MMVD.6 

  • Metabolomics research showed that the clinical benefits seen in the internal study were associated with positive changes at the molecular level.7,9 

conversation starter background image

“MMVD is a slowly progressive disease that may never affect the daily life of your dog. But about 30% of dogs with MMVD will progress to advanced disease.  A change in diet has long been recommended if heart failure develops to help manage clinical signs; however, there are also nutritional changes we can make right now. These nutritional changes are designed to address the altered metabolism seen in earlier stages of MMVD and may help slow progression. "

Related Tools and Content:

ACVIM Classification of Heart Disease and Heart Failure in Dogs with MMVD

View a short video about the ACVIM classification of heart disease.

Watch Video 1 min to 5 min

Myxomatous Mitral Valve Disease

Read about the science behind a novel nutritional intervention for dogs with early stage MMVD.

View Research 6 min to 10 min

Dietary management of myxomatous mitral valve disease (MMVD)

Myxomatous mitral valve disease (MMVD) is the most common heart disease in dogs. Learn about specific nutrients that play key roles in cardiac health for dogs with MMVD.

View Hot Topic 6 min to 10 min

Transforming Heart Health

A novel dietary intervention for dogs with early stage myxomatous mitral valve disease

View Monograph 20+ minutes

To Share With Pet Owner:

Nutrition and Heart Health

The heart is a vital organ that relies on specific nutrients and a continuous supply of energy to support and maintain a regular rate and rhythm, yet the role of nutrition in pets’ cardiac health is often overlooked.

View Hot Topic 6 min to 10 min

References

  1. Keene, B. W., Atkins, C. E., Bonagura, J. D., Fox, P. R., Häggström, J., Fuentes, V. L., Oyama, M. A., Rush, J. E., Stepien, R., & Uechi, M. (2019). ACVIM consensus guidelines for the diagnosis and treatment of myxomatous mitral valve disease in dogs. Journal of Veterinary Internal Medicine, 33(3), 1127–1140.
  2. Borgarelli, M., Crosara, S., Lamb, K., Savarino, P., La Rosa, G., Tarducci, A., & Häggström, J. (2012). Survival characteristics and prognostic variables of dogs with preclinical chronic degenerative mitral valve disease attributable to myxomatous degeneration. Journal of Veterinary Internal Medicine, 26(1), 69–75. doi: 10.1111/j.1939-1676.2011.00860.x.
  3. Buchanan, J. W. (1977). Chronic valvular disease (endocardiosis) in dogs. Advances in Veterinary Science, 21, 57–106.
  4. Parker, H. G., & Kilroy-Glynn, P. (2012). Myxomatous mitral valve disease in dogs: Does size matter? Journal of Veterinary Cardiology, 14(1), 19–29. doi:10.1016/j.jvc.2012.01.006
  5. Borgarelli, M., & Häggström, J. (2010). Canine degenerative myxomatous mitral valve disease: Natural history, clinical presentation and therapy. Veterinary Clinics of North America: Small Animal Practice, 40, 651–663.
  6. Li, Q., Heaney, A., Langenfeld-McCoy, N., Boler, B. V., & Laflamme, D. P. (2019). Dietary intervention reduces left atrial enlargement in dogs with early preclinical myxomatous mitral valve disease: A blinded randomized controlled study in 36 dogs. BMC Veterinary Research, 15(1), 425. doi: 10.1186/s12917-019-2169-1
  7. Li, Q., Laflamme, D. P., & Bauer, J. E. (2020). Serum untargeted metabolomic changes in response to diet intervention in dogs with preclinical myxomatous mitral valve disease. PloS One, 15(6), e0234404. doi: 10.1371/journal.pone.0234404
  8. Li, Q., Freeman, L.M. Rush, J.E., Huggins, G.S., Kennedy, A.D., Labuda, J.A., Laflamme, D.P., & Hannah, S.S. Veterinary medicine and multi-omics research for future nutrition targets: metabolomics and transcriptomics of the common degenerative mitral valve disease in dogs. (2015). OMICS, 19(8): 461-470. doi: 10.1089/omi.2015.0057 
  9. Li, Q., Larouche-Lebel, E., Loughran, K. A., Huh, T. P., Suchodolski, J. S., & Oyama, M. A. (2021). Metabolomics profiling analysis reveals deranged energy metabolism and amino acid metabolic reprogramming in dogs with myxomatous mitral valve disease. Journal of the American Heart Association, 10(9), e018923. doi: 10.1161/JAHA.120.018923.